Buspirone, but not sumatriptan, induces miosis in humans: Relevance for a serotoninergic pupil control

摘要: Background and objective Drugs that act on the serotoninergic system have been shown to influence pupil size. However, 5-hydroxytryptamine (5-HT) receptor type or subtype affects diameter has not defined in humans. With a placebo-controlled, double-blind randomized design, we investigated healthy volunteers effect size of buspirone sumatriptan, which mainly 5-HT1A− 5-HT1−like receptors, respectively. Methods The area was measured by means videopupillometer before after single oral administration placebo three different doses active drugs. Heart rate arterial blood pressure were recorded measurement. Results Buspirone (5, 10, 20 mg) caused dose-dependent miosis. Sumatriptan (50, 100, 200 did affect Twenty milligrams reduced mydriasis induced pretreatment with homatropine eyedrops. A mg dose without change heart rate, whereas buspirone, at lower than mg, sumatriptan pressure. Conclusions This study suggests but selective agonist 5-HT1-like causes miosis humans activation 5-HT1A possibly located central nervous where they inhibit iris sympathetic pathways. Measurement seems provide valuable sensitive index function humans. Clinical Pharmacology & Therapeutics (1995) 57, 349–355; doi: