Morphology of filamentous fungi: linking cellular biology to process engineering using Aspergillus niger.

摘要: In various biotechnological processes, filamentous fungi, e.g. Aspergillus niger, are widely applied for the production of high value-added products due to their secretion efficiency. There is, however, a tangled relationship between morphology these microorganisms, transport phenomena and related productivity. The morphological characteristics vary freely dispersed mycelia distinct pellets aggregated biomass. Hence, advantages disadvantages mycel or pellet cultivation have be balanced out carefully. Due this inadequate understanding morphogenesis fungal morphology, along with reproducibility inocula same quality, is often bottleneck productivity in industrial production. To obtain an optimisation process it great importance gain better molecular cell biology microorganisms as well approaches biochemical engineering particle technique, particular characterise interactions growth conditions, spore–hyphae-interactions product formation. Advances image analysis techniques micromechanical devices applications cultivations made available quantitative data on cells. This chapter provides ambitious aspects line action, focussing control characterisation gradients understand metabolism fungi. Based data, bottlenecks A. niger within complex pathways from gene should identified may improve yield.