Does oxygen free radical increased formation explain long term complications of diabetes mellitus

摘要: Oxygen free radicals (OFR) can form by reaction of glycated proteins with molecular oxygen. We hypothesize that this mechanism operates in tissues diabetic patients when their content is significantly increased. OFR are harmful to polyunsaturated fatty acids lipid membranes, proteins, sugars and DNA. The most significant complications diabetes, for example polyneuritis, retinopathy, microangiopathy, perforating ulcers, impaired healing, may depend on the excessive production proteins. Clues these effects be deduced from decrease glutathione stores red blood cells, increases peroxidation malondialdehyde formation, all which have been documented occur course diabetes mellitus.