The protective role of copper-zinc superoxide dismutase against alloxan-induced diabetes: morphological aspects.
作者： L. G. Thaete , R. K. Crouch , M. G. Buse , S. S. Spicer
DOI: 10.1007/BF00291975
关键词: Ultrastructure 、 Insulin 、 Diabetes mellitus 、 Extracellular 、 Enzyme 、 Immunostaining 、 Alloxan 、 Internal medicine 、 Superoxide dismutase 、 Endocrinology 、 Biology
摘要: Copper-zinc Superoxide dismutase is known to protect pancreatic β-cell function from the damage of alloxan. A morphological investigation copper-zinc prophylaxis against alloxan was undertaken in rats investigate mechanism this protective action. Exogenous reproducibly protected features β cells by as determined light microscopic immunostaining for insulin and ultrastructural examination. By same criteria, α δ appeared unaffected administration a combination superoxide or either agent alone. Autoradiography after injection 125I labelled into normal showed no evidence that enzyme enters viable islet cells, suggesting an extracellular site protection
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