Collagenolytic Enzymes and their Applications in Biomedicine.

摘要: Nowadays, enzymatic therapy is a very promising line of treatment for many different diseases. There group disorders and conditions, caused by fibrotic scar processes associated with the excessive accumulation collagen that needs to be catabolized normalize connective tissue content. The human body normally synthesizes special extracellular enzymes, matrix metalloproteases (MMPs) itself. These enzymes can cleave components (ECM) types thus maintain balance components. MMPs are multifunctional involved in variety organism processes. However, under pathological function not sufficient, these fail deal disease. Thus, medical intervention required. Enzymatic effective way treating such collagen-associated conditions. It involves application exogenous collagenolytic catabolize at affected site lead successful elimination Such synthesized organisms: bacteria, animals (especially marine organisms), plants fungi. most studied commercially available collagenases from Clostridium histolyticum pancreas crab Paralithodes camtschatica, due their ability effectively hydrolyse without affecting other tissues, wide pH ranges activity. In present review, we summarize only data concerning existing collagenase-based medications applications collagen-related diseases but also propose sources potential therapy.