Optimizing Wound Bed Preparation With Collagenase Enzymatic Debridement

摘要: Difficult-to-heal and chronic wounds affect tens of millions people worldwide. In the U.S. alone, direct cost for their treatment exceeds $25 billion. Yet despite advances in wound research that have markedly improved patient care, healing is often delayed weeks or months. For venous diabetic ulcers, complete closure achieved as few 25%-50% hard-to-heal wounds. Wound bed preparation consistent application appropriate effective debridement techniques are recommended optimized The TIME paradigm (Tissue, Inflammation/infection, Moisture balance Edge wound) provides a model to remove barriers optimize process. While we think an episodic event occurs specific care giver/patient interface. There possibility maintenance which medication can assist both macroscopic microscopic wound. We review various therapies available clinicians United States, explore characteristics capabilities clostridial collagenase ointment (CCO), type enzymatic debridement, potentially allows epithelialization while debriding. It appears case CCO it may exert this influences by removal necrotic plug promoting granulation sustaining epithelialization. also easily combined with other methods selective tissue, has been safely used populations. body evidence indicated concept especially when add efficacious, safe cost-effective choice cutaneous ulcers burn will likely play expanding role all phases preparation.