摘要: Cancers of the skin are a very common type human malignancy, encompassing basal cell carcinoma, squamous and melanoma. Of three main types cancer, roles PKC isozymes in carcinoma have been most extensively studied due to agonist activity phorbol ester tumor promoters used mouse chemical carcinogenesis model. These studies identified with oncogenic (PKCe) or tumor-suppressive (PKCδ, PKCη) activities. The activation response UV radiation, etiological agent for cancers, has also implicated unique etiology. More recently, examining isozyme expression function malignant melanoma uncovered isozyme-specific changes these cancers as well. This chapter will summarize our current understanding well their normal keratinocyte melanocyte biology.
springer.com
sci-hub.st 参考文章(147)
Mary E. Reyland, Protein Kinase C and Apoptosis Apoptosis, Cell Signaling, and Human Diseases. pp. 31- 55 ,(2006) , 10.1007/978-1-59745-199-4_2
H.Y. Park, V. Russakovsky, S. Ohno, B.A. Gilchrest, The beta isoform of protein kinase C stimulates human melanogenesis by activating tyrosinase in pigment cells. Journal of Biological Chemistry. ,vol. 268, pp. 11742- 11749 ,(1993) , 10.1016/S0021-9258(19)50262-9
Mitchell F. Denning, Christina Cheng, Erin K. Williams, Stuart H. Yuspa, Alpa G. Dharia, Andrzej A. Dlugosz, Alterations in Murine Keratinocyte Differentiation Induced by Activated rasHa Genes Are Mediated by Protein Kinase C-α Cancer Research. ,vol. 54, pp. 6413- 6420 ,(1994)
Deric L Wheeler, Kristin J Ness, Ajit K Verma, Terry D Oberley, Protein kinase Cepsilon is linked to 12-O-tetradecanoylphorbol-13-acetate-induced tumor necrosis factor-alpha ectodomain shedding and the development of metastatic squamous cell carcinoma in protein kinase Cepsilon transgenic mice. Cancer Research. ,vol. 63, pp. 6547- 6555 ,(2003)
Toshio Kuroki, Tohgo Ikuta, Akiko Murakami, Kazuhiro Chida, Tomoko Tagawa, Cholesterol sulfate, a second messenger for the η isoform of protein kinase C, inhibits promotional phase in mouse skin carcinogenesis Cancer Research. ,vol. 55, pp. 4865- 4869 ,(1995)
Christophe Cataisson, Andrea J. Pearson, Sara Torgerson, Sergei A. Nedospasov, Stuart H. Yuspa, Protein Kinase Cα-Mediated Chemotaxis of Neutrophils Requires NF-κB Activity but Is Independent of TNFα Signaling in Mouse Skin In Vivo Journal of Immunology. ,vol. 174, pp. 1686- 1692 ,(2005) , 10.4049/JIMMUNOL.174.3.1686
Alberto N. Raick, Ultrastructural, Histological, and Biochemical Alterations Produced by 12-O-Tetradecanoyl-phorbol-13-acetate on Mouse Epidermis and Their Relevance to Skin Tumor Promotion Cancer Research. ,vol. 33, pp. 269- 286 ,(1973)
Christian Delphi, Kuo-Ping Huang, Christian Scotto, Agnes Chapel, Mathilde Vincon, Edmond Chambaz, Jerome Garin, Jacques Baudier, The in Vitro Phosphorylation of P53 by Calcium‐Dependent Protein Kinase C FEBS Journal. ,vol. 245, pp. 684- 692 ,(1997) , 10.1111/J.1432-1033.1997.T01-1-00684.X
Terry Magnuson, David W. Threadgill, David W. Threadgill, Christina Cheng, Laura Hansen, Robert J. Coffey, Stuart H. Yuspa, Andrzej A. Dlugosz, Mitchell F. Denning, Mitchell F. Denning, Natalie Alexander, Targeted disruption of the epidermal growth factor receptor impairs growth of squamous papillomas expressing the v-ras(Ha) oncogene but does not block in vitro keratinocyte responses to oncogenic ras. Cancer Research. ,vol. 57, pp. 3180- 3188 ,(1997)
Robert J. Moore, David M. Owens, Gordon Stamp, Caroline Arnott, Frances Burke, Nick East, Hazel Holdsworth, Lynn Turner, Barrett Rollins, Manolis Pasparakis, George Kollias, Frances Balkwill, Mice deficient in tumor necrosis factor-alpha are resistant to skin carcinogenesis. Nature Medicine. ,vol. 5, pp. 828- 831 ,(1999) , 10.1038/10552