Localization and expression of cartilage oligomeric matrix protein by human rheumatoid and osteoarthritic synovium and cartilage.
作者： Paul E. Di Cesare , Carrie Fang , Michael P. Leslie , Craig J. Della Valle , Julie M. Gold
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摘要: Synovium and cartilage from patients with osteoarthritis or rheumatoid arthritis were analyzed for expression of oligomeric matrix protein. Immunostaining synovium antiserum to protein demonstrated positive staining in both diseases. In osteoarthritis, there was within the synovial cells immediately subjacent connective tissue, less intense deeper tissue. arthritis, marked situ hybridization performed an antisense digoxigenin-labeled riboprobe human confirmed presence mRNA lining types synovium. Quantitative polymerase chain reaction a MIMIC increased as compared osteoarthritic synovium, respectively; levels similar those chondrocytes. As result high inflammatory should be considered potential tissue source any investigation biological markers metabolism. The upregulated tissues suggests its vivo regulation by cytokines.
sci-hub.se 参考文章(31)
D L Goldenberg, A S Cohen, M S Egan, Inflammatory synovitis in degenerative joint disease. The Journal of Rheumatology. ,vol. 9, pp. 204- 209 ,(1982)
J L Funk, L A Cordaro, H Wei, J B Benjamin, D E Yocum, Genetic dissection of SLE pathogenesis. Sle1 on murine chromosome 1 leads to a selective loss of tolerance to H2A/H2B/DNA subnucleosomes. Journal of Clinical Investigation. ,vol. 101, pp. 1362- 1372 ,(1998) , 10.1172/JCI728
E Hedbom, P Antonsson, A Hjerpe, D Aeschlimann, M Paulsson, E Rosa-Pimentel, Y Sommarin, M Wendel, A Oldberg, D Heinegård, Cartilage matrix proteins. An acidic oligomeric protein (COMP) detected only in cartilage. Journal of Biological Chemistry. ,vol. 267, pp. 6132- 6136 ,(1992) , 10.1016/S0021-9258(18)42671-3
A Oldberg, P Antonsson, K Lindblom, D Heinegård, COMP (cartilage oligomeric matrix protein) is structurally related to the thrombospondins. Journal of Biological Chemistry. ,vol. 267, pp. 22346- 22350 ,(1992) , 10.1016/S0021-9258(18)41677-8
M Mörgelin, D Heinegård, J Engel, M Paulsson, Electron microscopy of native cartilage oligomeric matrix protein purified from the Swarm rat chondrosarcoma reveals a five-armed structure. Journal of Biological Chemistry. ,vol. 267, pp. 6137- 6141 ,(1992) , 10.1016/S0021-9258(18)42672-5
Paul DiCesare, Nik Hauser, Daniel Lehman, Subhalakshmi Pasumarti, Mats Paulsson, Cartilage oligomeric matrix protein (COMP) is an abundant component of tendon FEBS Letters. ,vol. 354, pp. 237- 240 ,(1994) , 10.1016/0014-5793(94)01134-6
Gail Newton, Stanislawa Weremowicz, Cynthia C. Morton, Neal G. Copeland, Debra J. Gilbert, Nancy A. Jenkins, Jack Lawler, Characterization of Human and Mouse Cartilage Oligomeric Matrix Protein Genomics. ,vol. 24, pp. 435- 439 ,(1994) , 10.1006/GENO.1994.1649
I. F. Petersson, T. Boegard, B. Svensson, D. Heinegard, T. Saxne, Changes in cartilage and bone metabolism identified by serum markers in early osteoarthritis of the knee joint. Rheumatology. ,vol. 37, pp. 46- 50 ,(1998) , 10.1093/RHEUMATOLOGY/37.1.46
Esbjörn Larsson, A Müssener, Dick Heinegård, Lars Klareskog, Tore Saxne, Increased serum levels of cartilage oligomeric matrix protein and bone sialoprotein in rats with collagen arthritis. Rheumatology. ,vol. 36, pp. 1258- 1261 ,(1997) , 10.1093/RHEUMATOLOGY/36.12.1258
Paul E. Di Cesare, Cathy S. Carlson, Elliot S. Stolerman, Nik Hauser, Hermina Tulli, Mats Paulsson, Increased degradation and altered tissue distribution of cartilage oligomeric matrix protein in human rheumatoid and osteoarthritic cartilage Journal of Orthopaedic Research. ,vol. 14, pp. 946- 955 ,(1996) , 10.1002/JOR.1100140615