Progression of hypertrophic cardiomyopathy into a hypokinetic left ventricle: Higher incidence in patients with midventricular obstruction

摘要: The development of segmental or generalized left ventricular hypokinesia is an unusual occurrence in patients with hypertrophic cardiomyopathy. To determine the incidence and possible pathophysiologic mechanisms responsible for this process, serial clinical laboratory data 62 diagnosis cardiomyopathy were analyzed. During a mean follow-up period 8 years (range 2 to 21), 5 (Group A) developed hypokinesia, whereas remaining 57 B) continued exhibit findings Three dilated ventricle hypokinesia; two other had wall motion abnormalities. None these five who fixed coronary artery disease. age, sex, duration follow-up, presence myocardial bridges angina pectoris, interventricular gradient all similar Groups A B. Mid obliteration was seen 4 (80%) Group (7%) B (p Findings from study reveal that can develop absence Such occur after acute infarction it gradually without electrocardiographic evidence infarction. Patients midventricular variant are at higher risk developing diffuse hypokinesia.