Collagen induced arthritis increases secondary metastasis in MMTV-PyV MT mouse model of mammary cancer

摘要: Several studies have demonstrated that sites of chronic inflammation are often associated with the establishment and growth various malignancies. A common inflammatory condition in humans is autoimmune arthritis (AA). Although AA cancer different diseases, many underlying processes contribute to disorders joints connective tissue characterize also affect progression metastasis. Systemically, can lead cellular infiltration lungs. reported statistically significant risk ratios between breast cancer. Despite this knowledge being available, there has been minimal research linking cancer, arthritis, metastasis Notably both diseases extremely prevalent older post-menopausal women. To establish novel link induced secondary PyV MT mice spontaneously develop mammary gland carcinoma were injected Type II collagen (CII) induce at 9 18 weeks age for pre-metastatic metastatic condition. The microenvironment evaluated. increase cancer-associated lungs bones was observed arthritic versus non-arthritic along an primary tumor burden. We report increases levels interstitial infiltrates pro-inflammatory cytokines such as interleukin-17 (IL-17), interleukin-6 (IL-6), Pro- Matrix metallopeptidase (Pro-MMP9), insulin like factor-II (GF-II) macrophage colony stimulating factor (M-CSF) lung bone milieu well circulation. These may be factors facilitating mice. This further substantiated by treatment celecoxib, anti-inflammatory drug + αIL-17 antibody significantly reduced bone. data generated not only reveal mechanism high susceptibility but our combination therapies modalities will capable reducing burden, preventing relapse patients