Acute inflammation induced by the biopsy of mouse mammary tumors promotes the development of metastasis

摘要: Development of metastasis in peripheral tissues is a major problem the fight to cure breast cancer. Although it becoming evident that chronic inflammation can contribute tumor progression and metastasis, effect acute primary less known. Using mouse models for cancer here we show biopsy mammary tumors increases frequency lung metastases. This associated with recruitment inflammatory cells elevated levels certain cytokines such as IL-6 airways. Antiinflammatory treatment prior after reduces development metastases triggered by biopsy. In addition, while lack does not affect development, protects from increasing number upon Thus, our studies addition inflammation, immune response caused invasive procedures may cause an increased risk on metastases, but could be decreased anti-inflammatory treatments.