Steady-state blood volume measurements in experimental tumors with different angiogenic burdens a study in mice.

摘要: PURPOSE: To experimentally validate the effectiveness of magnetic resonance (MR) imaging enhanced with long-circulating iron oxide for measurement vascular volume fractions (VVFs) as indicators angiogenesis in different experimental tumor models. MATERIALS AND METHODS: Tumors differing degrees angiogenesis—9L rodent gliosarcoma, DU4475 human mammary adenocarcinoma, HT1080 fibrosarcoma, and EOMA hemangioendothelioma—were implanted nude mice. Tumoral VVFs were measured at submillimeter voxel resolutions by using 1.5-T MR imaging. A technetium-labeled intravascular radiotracer was injected into a subset animals to measurements. Microvessel density endothelial growth factor (VEGF) also measured. Statistical analysis performed variance. RESULTS: High-resolution multisection maps blood obtained all Mean tumoral VVF differed significantly among tumors: 2.1% ± 0.3 (st...