Ultrasmall superparamagnetic iron oxide: an intravenous contrast agent for assessing lymph nodes with MR imaging.

摘要: An ultrasmall superparamagnetic iron oxide (USPIO) preparation was evaluated as a potential intravenous contrast agent for lymph nodes. Relaxation time measurements and magnetic resonance (MR) imaging were performed in rats with normal nodes node metastases. In animals, relaxation times decreased maximally within 24-48 hours after administration of USPIO. Twenty-four administration, the T2 had from 74 msec +/- 2.2 to 30 0.7 (USPIO, 40 mumol per kilogram) or 15 0.0 (200 Fe/kg), whereas metastatic did not change. MR animal model nodal metastases confirmed hypothesis that intravenously administered USPIO decreases signal intensity but A single may allow detection on basis characteristics rather than currently used, insensiti...