Glutamine in Animal Science and Production

摘要: With its many proposed metabolic roles, glutamine would seem to have major potential in normal animal production systems as well during situations involving adverse challenges. In practice, however, responses supplementation been inconsistent. Thus, lactation and growth studies ruminants, both positive null effects on reported. Similarly, therapeutic various digestive tract disorders inconsistent pigs ruminants. This is despite a proven involvement the nucleic acid biosynthesis necessary support cell proliferation. sheep, at least, may exert protective effect against hepatic amino (AA) oxidation, particularly for methionine. offer anabolic because methionine first limiting AA number of feedstuffs. Glutamine also important control acidosis, but, contrast rodents, main site seems be extra-hepatic. immune system, while lymphocyte proliferation glutamine-dependent, intracellular concentrations are low (in other tissues, such muscle liver). Instead, glutamate accumulated, but majority this (approximately 65%) derived vivo from plasma glutamine. endotoxin challenge elevates flux glutamine, with corresponding decrease concentration. At same time, accumulation fractional rate protein synthesis within lymphocytes enhanced. These responses, not altered by an supplement that contains Overall, although obviously plays roles body, does appear provide consistent beneficial or effects, except certain catabolic situations. availability, therefore, limitation Rather, signal alterations nutrient demands among organs better understanding role increase where modulation status beneficial.