Classical Hodgkin Lymphoma and Nodular Lymphocyte Predominant Hodgkin Lymphoma

摘要: Hodgkin lymphoma (HL) is a rather unique neoplasm. In contrast to most other lymphomas, and indeed malignancies in general, the bulk of infiltrate tissues affected by HL comprised non-neoplastic T cells, B-cells, macrophages, eosinophils, neutrophils, plasma while neoplastic cells are rare, accounting for only approximately 1% tumor mass. The include hallmark binucleated large Reed–Sternberg morphologic variants thereof, which collectively referred as Hodgkin/Reed–Sternberg (HRS) cells. Intricate bi-directional signaling between this pleomorphic, reactive background integral tumor’s pathobiology clinical features, with an evaluation various being central contemporary diagnosis classification. Another unusual feature that whereas cell origin lymphomas can almost always be correlated specific stage lymphoid maturation, HRS do not have morphologically immunophenotypically identifiable normal hematopoietic counterpart. fact, but characteristic immunophenotype includes antigens typically found on spectrum such dendritic granulocytes, monocytes, cells., For these reasons (rarity within confusing immunophenotype), determining ontogeny had been technically challenging. Additional impediments characterizing included presence several lines no animal model.