Benign Fibroblastic Polyps of the Colon: A Histologic, Immunohistochemical, and Ultrastructural Study

摘要: Mesenchymal proliferations presenting as mucosal polyps are relatively uncommon and represented by gastrointestinal stromal tumors, smooth muscle neural inflammatory fibroid polyps. In this report, we describe the clinicopathologic features of a distinctive type polyp composed cytologically bland spindled cells with fibroblastic features. Fourteen cases histologic of"fibroblastic polyps" were identified from our case files January 2000 to December 2003. The clinical endoscopic findings reviewed. Immunohistochemistry using panel antibodies (vimentin, actin, desmin, CD31, CD34, Bcl-2, c-Kit, S-100, epithelial membrane antigen) was performed in all cases, electron microscopy two cases. lesions solitary not associated an identifiable polyposis syndrome. Associated adenomata and/or hyperplastic at different sites present 10 seen close association 3 These characterized monomorphic spindle cell proliferation lamina propria, without necrosis or mitotic activity. intimately muscularis mucosae resulted wide separation disorganization colonic crypts. Immunohistochemical analysis revealed strong diffuse positivity for vimentin only. Weak focal reactivity noted 2 CD34 while staining other negative. Electron sparse cytoplasmic organelles many intermediate filaments. histology ultrastructural immunohistochemical suggestive differentiation these cells. summary, represent that should be distinguished tract.