Cobrotoxin extracted from Naja atra venom relieves arthritis symptoms through anti-inflammation and immunosuppression effects in rat arthritis model

摘要: Abstract Ethnopharmacological relevance The Naja atra (Chinese cobra), primarily distributing in the low or medium altitude areas of southern China and Taiwan, was considered as a medicine traditional Chinese used to treat pain, inflammation arthritis. Aim study To anti-inflammatory anti-arthritic activities cobrotoxin (CTX), an active component venom from . Materials methods Adjuvant-induced arthritis (AA) rats were animal model rheumatoid effects CTX evaluated through score, paw edema histopathology changes joints. anti-inflammation assayed by level IL-6, TNF-α, IL-1β number inflammatory cells peripheral blood, well proliferation fibroblast-like synoviocytes (FLS). immune valued T CD4 CD8. Results alleviated disease development AA according ameliorating character. At meanwhile, decreased levels numbers blood. also suppressed abnormal increasing CD4+ cells/ CD8+ ratio, could significantly inhibit cell proliferation. Consistent with its on inhibiting granuloma's formation, inhibited cultured FLSs. Further studies signaling FLSs revealed that NF-κB pathway. Conclusions has beneficial regulation effects. inhibition pathway partly contributes properties CTX.