Cobrotoxin from Naja naja atra Venom Ameliorates Adriamycin Nephropathy in Rats

摘要: Chronic kidney disease (CKD) becomes a global health problem with high morbidity and mortality. Adriamycin- (ADR-) induced rodent chronic nephropathy is classic experimental model of human minimal lesion nephrotic syndrome. The present study investigated the effect cobrotoxin (CTX) on ADR-induced nephropathy. Rats were given 6 mg/kg ADR once through tail vein to replicate model. CTX was administered rats daily by placing fast dissolving membrane strip under tongue starting from 5 days prior administration until end experiment. results showed that ameliorated symptoms syndrome reduced body weight loss, proteinuria, hypoalbuminemia, dyslipidemia, serum electrolyte imbalance, oxidative stress, renal function abnormities, pathological lesions. Anti-inflammatory cytokine IL-10 expression elevated after in inhibited phosphorylation IκB-α NF-κB p65 nuclear translocation. Meanwhile, upregulated protein level podocyte-specific nephrin downregulated fibrosis-related TGF-β. These findings suggest may be potential drug for diseases.