Angiotensin II stimulates respiration in awake dogs and antagonizes baroreceptor inhibition

摘要: Abstract The effects of intravenous infusions physiologic doses angiotensin II (AII) on expired ventilation (V E ) and acid-base balance were examined in awake dogs. A control infusion saline was followed by AII infusion, initially with mean arterial pressure (MAP) raised 15%, then MAP at levels concurrent sodium nitroprusside (SNP). To for SNP, the protocol repeated using arginine vasopressin (AVP). Ventilatory responses CO 2 (VRC) measured end these protocols separately elevated during AII. With AVP, increased inhibitedV , heart rate (HR) metabolism. However, stimulation opposed baroreceptor reflexes variables, as well plasma did not change. When lowered to all variables increased. AII, Pa followedV changes, decreasing 3 Torr levels; however, [H + ] remained constant due a decrease strong ion difference. stimulatory SNP; SNP stimulateV AVP infusion. slope VRC unaltered or MAP; reduced slope. Physiological increases other systems normal maintain several regulatory inhibition.