Hepatic proteome analysis of Atlantic salmon (Salmo salar) after exposure to environmental concentrations of human pharmaceuticals.

摘要: Pharmaceuticals are pseudopersistent aquatic pollutants with unknown effects at environmentally relevant concentrations. Atlantic salmon (Salmo salar) were exposed to Acetaminophen: 54.77 ± 34.67; Atenolol: 11.08 7.98, and Carbamazepine: 7.85 0.13 μg·L(-1) for 5 days. After Acetaminophen treatment, 19 proteins differently expressed, of which 11 significant respect the control group (eight up-regulated three down-regulated). Atenolol seven expressed obtained in comparison control, six could be identified (four two Carbamazepine exposure resulted 15 compared 10 them (seven Out these, features common between one Atenolol. One feature was across all treatments. Principal component analysis heat map clustering showed a clear grouping variability caused by applied The data suggest (1) that concentrations pharmaceuticals alters hepatic protein expression profile salmon; (2) existence treatment specific processes may useful biomarker development.