Hepatotoxicity of atenolol therapy - A report of 2 cases
作者： Somnath Mondal , Saibal Das , Sanjib Bandyopadhyay , Ankur Datta , Souvik Sardar
DOI: 10.1016/S2221-6189(13)60137-7
关键词:
摘要: Abstract This case report highlights atenolol induced episodes of chronic and acute hepatotoxicities in 2 elderly hypertensive patients. The 1st patient manifested liver dysfunction after 8 months 50 mg daily therapy the 2nd was revealed within 3 weeks 100 intake. There no evidence any other possible hereditary, traumatic, surgical, metabolic, infective, organic, or pathologic causes giving rise to these conditions. Possibilities drug interactions were carefully ruled out ‘probably’ (atenolol) induced, as depicted by CIOMS/RUCAM scale. Withdrawal offending resulted reversal diseased states. Routine function tests may be warranted patients on therapy.
jadweb.org 参考文章(18)
William M. Lee, Sandeep Lahoti, HEPATOTOXICITY OF ANTICHOLESTEROL, CARDIOVASCULAR, AND ENDOCRINE DRUGS AND HORMONAL AGENTS Gastroenterology Clinics of North America. ,vol. 24, pp. 907- 922 ,(1995) , 10.1016/S0889-8553(21)00233-8
M Garcia‐Cortes, MI Lucena, K Pachkoria, Y Borraz, R Hidalgo, RJ Andrade, SPANISH GROUP FOR THE STUDY OF DRUG‐INDUCED LIVER DISEASE (GRUPO DE ESTUDIO PARA LAS HEPATOPATÍAS ASOCIADAS A MEDICAMENTOS, GEHAM), None, Evaluation of naranjo adverse drug reactions probability scale in causality assessment of drug-induced liver injury. Alimentary Pharmacology & Therapeutics. ,vol. 27, pp. 780- 789 ,(2008) , 10.1111/J.1365-2036.2008.03655.X
Tony R. Bai, Adrenergic Agonists and Antagonists Wiley‐Blackwell. pp. 668- 682 ,(2009) , 10.1002/9781444300918.CH28
Einar Björnsson, Pernilla Jerlstad, Annika Bergqvist, Rolf Olsson, Fulminant drug-induced hepatic failure leading to death or liver transplantation in Sweden. Scandinavian Journal of Gastroenterology. ,vol. 40, pp. 1095- 1101 ,(2005) , 10.1080/00365520510023846
Eiji Kutoh, Possible metformin-induced hepatotoxicity. American Journal of Geriatric Pharmacotherapy. ,vol. 3, pp. 270- 273 ,(2005) , 10.1016/J.AMJOPHARM.2005.12.002
M D Rawlins, Clinical pharmacology. Adverse reactions to drugs. BMJ. ,vol. 282, pp. 974- 976 ,(1981) , 10.1136/BMJ.282.6268.974
S.W. Yusuf, R.M. Mishra, Hepatic dysfunction associated with atenolol The Lancet. ,vol. 346, pp. 192- ,(1995) , 10.1016/S0140-6736(95)91255-X
Adrian Reuben, David G. Koch, William M. Lee, Drug-Induced Acute Liver Failure: Results of a U.S. Multicenter, Prospective Study Hepatology. ,vol. 52, pp. 2065- 2076 ,(2010) , 10.1002/HEP.23937
F. Miralles-Linares, S. Puerta-Fernandez, M. R. Bernal-Lopez, F. J. Tinahones, R. J. Andrade, R. Gomez-Huelgas, Metformin-Induced Hepatotoxicity Diabetes Care. ,vol. 35, ,(2012) , 10.2337/DC11-2306
R.C. Heel, R.N. Brogden, T.M. Speight, G.S. Avery, Atenolol: A Review of its Pharmacological Properties and Therapeutic Efficacy in Angina Pectoris and Hypertension Drugs. ,vol. 17, pp. 425- 460 ,(1979) , 10.2165/00003495-197917060-00001