Neuroimaging after mild traumatic brain injury: Review and meta-analysis

摘要: This paper broadly reviews the study of mild traumatic brain injury (mTBI), across spectrum neuroimaging modalities. Among range imaging methods, however, magnetic resonance (MRI) is unique in its applicability to studying both structure and function. Thus we additionally performed meta-analyses MRI results examine 1) issue anatomical variability consistency for functional (fMRI) findings, 2) analogous white-matter 3) importance accounting time post diffusion weighted reports. As discuss, human literature consists small large studies spanning acute chronic points that have examined structural changes with mTBI, using virtually every available medical modality. Two key commonalities been used majority studies. The first comparison between mTBI control populations. second attempt link neuropsychological assessments. Our fMRI meta-analysis demonstrates a frontal vulnerability demonstrated by decreased signal prefrontal cortex compared controls. further highlighted examining frequency reported white matter anisotropy, which show strong anterior-to-posterior gradient (with anterior regions being more frequently mTBI). final DTI examines debated topic arising from inconsistent anisotropy findings support hypothesis associated elevated values complaints are correlated depressed anisotropy. Thus, this review set demonstrate several important about ongoing use understand occur throughout course recovery. Based on complexity much work area required characterize mechanisms recovery factors achieve clinically-relevant capabilities diagnosis.