Why have we not yet developed a simple blood test for TBI

摘要: In recent years, traumatic brain injury (TBI) has emerged as a rapidly growing public health challenge. Annually, approximately 1.7 million people will sustain TBI in the USA and WHO named leading cause of death disability young adults worldwide, predicting it become third general population by 2020. The medical community currently relies on clinical examination various neuroimaging modalities for diagnosis TBI; however, these methodologies are often confounded altered patient mental status particularly poor at identifying mild-to-moderate injury. Despite decades basic research, identification hundreds biochemical markers, presently there is no blood test to objectively assess severity. Recent work suggests treatment-induced variance brain’s glymphatic clearance may be responsible breakdown between biomarker discovery translation.