Oculomotor, Vestibular, and Reaction Time Tests in Mild Traumatic Brain Injury

作者: Carey Balaban , Michael E. Hoffer , Mikhaylo Szczupak , Hillary Snapp , James Crawford

DOI: 10.1371/JOURNAL.PONE.0162168

关键词:

摘要: Objective Mild traumatic brain injury is a major public health issue and particular concern in sports. One of the most difficult issues with respect to mild involves diagnosis disorder. Typically, made by constellation physical exam findings. However, order best manage injury, it critically important develop objective tests that substantiate diagnosis. With disorder can be better characterized, more accurately diagnosed, studied effectively. In addition, prevention treatments applied where necessary. Methods Two cohorts each fifty subjects one hundred controls were evaluated battery oculomotor, vestibular reaction time related population individuals as compared controls. Results We demonstrated pattern differences between two groups showed how three these yield an 89% sensitivity 95% specificity for confirming current injury. Interpretation These results help characterize vestibular, those non-affected individuals. This characterization will allow development effective point care neurologic diagnostic techniques targeted treatment which may quicker return normal activity.

参考文章(21)
Laura Lei-Rivera, John Sutera, Jessica A. Galatioto, Bryan D. Hujsak, James M. Gurley, Special tools for the assessment of balance and dizziness in individuals with mild traumatic brain injury. NeuroRehabilitation. ,vol. 32, pp. 463- 472 ,(2013) , 10.3233/NRE-130869
Sujana S. Chandrasekhar, The assessment of balance and dizziness in the TBI patient NeuroRehabilitation. ,vol. 32, pp. 445- 454 ,(2013) , 10.3233/NRE-130867
Benjamin A Plog, Maiken Nedergaard, Why have we not yet developed a simple blood test for TBI Expert Review of Neurotherapeutics. ,vol. 15, pp. 465- 468 ,(2015) , 10.1586/14737175.2015.1031112
Aliyah R. Snyder, Russell M. Bauer, , A Normative Study of the Sport Concussion Assessment Tool (SCAT2) in Children and Adolescents Clinical Neuropsychologist. ,vol. 28, pp. 1091- 1103 ,(2014) , 10.1080/13854046.2014.952667
Jasper O. Chang, Susan S. Levy, Seth W. Seay, Daniel J. Goble, An alternative to the balance error scoring system: using a low-cost balance board to improve the validity/reliability of sports-related concussion balance testing. Clinical Journal of Sport Medicine. ,vol. 24, pp. 256- 262 ,(2014) , 10.1097/JSM.0000000000000016
Matthew R. Scherer, Holly Burrows, Robin Pinto, Philip Littlefield, Louis M. French, Aaron K. Tarbett, Michael C. Schubert, Evidence of central and peripheral vestibular pathology in blast-related traumatic brain injury. Otology & Neurotology. ,vol. 32, pp. 571- 580 ,(2011) , 10.1097/MAO.0B013E318210B8FA
Vardhman K. Rakyan, Thomas A. Down, David J. Balding, Stephan Beck, Epigenome-wide association studies for common human diseases Nature Reviews Genetics. ,vol. 12, pp. 529- 541 ,(2011) , 10.1038/NRG3000
Laurie A. King, Fay B. Horak, Martina Mancini, Donald Pierce, Kelsey C. Priest, James Chesnutt, Patrick Sullivan, Julie C. Chapman, Instrumenting the Balance Error Scoring System for Use With Patients Reporting Persistent Balance Problems After Mild Traumatic Brain Injury Archives of Physical Medicine and Rehabilitation. ,vol. 95, pp. 353- 359 ,(2014) , 10.1016/J.APMR.2013.10.015
Douglas P. Munoz, Stefan Everling, Look away: the anti-saccade task and the voluntary control of eye movement Nature Reviews Neuroscience. ,vol. 5, pp. 218- 228 ,(2004) , 10.1038/NRN1345