Contact dermatitis considerations in atopic dermatitis

摘要: Complex immunologic pathways, influenced by both genetic and environment triggers, contribute to the development of atopic dermatitis allergic contact dermatitis. Suppressing mechanisms between Th1-driven Th2-driven conditions were thought reduce simultaneous expression both; however, recent evidence indicates that pediatric patients with are likely develop clinically relevant positive patch tests more react specific allergens, such as lanolin. We review potential role skin barrier defects, filaggrin mutations impaired function, including aberrancies in epidermal pH buffering capabilities, which may promote bacterial biofilms create an favoring sensitization.