Incidence of gastroenteropancreatic neuroendocrine tumours: a systematic review of the literature

摘要: Based on the current medical literature, worldwide incidence of neuroendocrine tumours (NETs) seems to have increased; however, a systematic literature overview is lacking. This study aimed collect all available data gastroenteropancreatic (GEP)-NETs and characteristics population establish their epidemiology. A sensitive MEDLINE search was carried out. The papers were selected via cascade process that restricted initial pool 7991 articles 33, using predefined inclusion exclusion criteria. Original evaluating sporadic GEP-NETs in regional, institutional national registries considered. majority originated from US National Cancer Institute Surveillance, Epidemiology End Results database cancer Western Europe. Generally, because retrospective nature existing databases outcomes studies might be biased, which hinders drawing firm conclusions. age-adjusted has increased steadily over past four decades (1973-2007), increasing 3.65-fold USA 3.8- 4.8-fold UK. Incidence changed variably one anatomical site another. greatest increase occurred for gastric rectal NETs, while smallest small intestine NETs. There gender racial differences, differed by and, some cases, time. rates (IRs) significantly last 40 years. Data are only North America, Europe Japan. site-by-site analysis revealed IRs NETs more than those others.