Risk of pancreatic cancer in patients with systemic lupus erythematosus: a meta-analysis

摘要: Accumulating evidences suggest that the incidence of several cancers is higher in systemic lupus erythematosus (SLE) than general population. However, finding on pancreatic cancer risk inconsistent. This meta-analysis aimed to determine whether SLE patients are at for cancer. We searched PubMed, Embase, and Cochrane database screen studies meeting our criteria. The hazard ratios (HRs) its 95% confidence interval (CIs) were calculated from a meta-analysis. Eleven cohort included final analysis. Overall, with had an increased (HR = 1.42, CI = 1.32–1.53). In subgroup analysis, hospital-based (HR = 1.43, CI = 1.32–1.54), retrospective over 10 years followed (HR = 1.44, CI = 1.33–1.55), low-quality CI = 1.31–1.53) remained robust. Significant publication bias was not observed among (p = 0.533). synthesized evidence demonstrated associated A well-designed, long-period study needed confirm this association.