Epidemiology and risk factors for colonization and infection by Acinetobacter baumannii in an ICU in Tunisia, where this pathogen is endemic

作者: Nozha Brahmi , Olfa Beji , Nour Abidi , Nadia Kouraichi , Youssef Blel

DOI: 10.1007/S10156-007-0557-0

关键词:

摘要: Because Acinetobacter baumannii has become an alarming endemic pathogen in our country we decided to conduct this prospective study, from January 2004 December 2005, order determine risk factors and outcomes involved clinical colonization or infection by A. a 16-bed Tunisian intensive care unit (ICU). One hundred two isolates were obtained 63 patients, with rate of 45%. The multidrug-resistant (MDR) was 39% during the 2-year epidemic outbreak October 2004. This followed closure all ICU rooms selective intestinal decontamination polymyxin. During 12-month post-intervention program (January–December 2005), declined. analysis for spread showed that only Simplified Acute Physiological Score (SAPS II) involved. On other hand, no factor identified multidrug resistance patients either colonized infected baumannii. There statistically significant difference crude mortality (67.5% MDR vs 46.7% susceptible baumannii; P = 0.04).

参考文章(29)
E Bergogne-Bérézin, K J Towner, Acinetobacter spp. as nosocomial pathogens: microbiological, clinical, and epidemiological features. Clinical Microbiology Reviews. ,vol. 9, pp. 148- 165 ,(1996) , 10.1128/CMR.9.2.148
E. Robenshtok, M. Paul, L. Leibovici, A. Fraser, S. Pitlik, I. Ostfeld, Z. Samra, S. Perez, B. Lev, M. Weinberger, The significance of Acinetobacter baumannii bacteraemia compared with Klebsiella pneumoniae bacteraemia: risk factors and outcomes. Journal of Hospital Infection. ,vol. 64, pp. 282- 287 ,(2006) , 10.1016/J.JHIN.2006.06.025
Xavier Corbella, Abelardo Montero, Miquel Pujol, M. Angeles Domínguez, Josefina Ayats, M. José Argerich, Frederic Garrigosa, Javier Ariza, Francesc Gudiol, EMERGENCE AND RAPID SPREAD OF CARBAPENEM RESISTANCE DURING A LARGE AND SUSTAINED HOSPITAL OUTBREAK OF MULTIRESISTANT ACINETOBACTER BAUMANNII Journal of Clinical Microbiology. ,vol. 38, pp. 4086- 4095 ,(2000) , 10.1128/JCM.38.11.4086-4095.2000
K. Amazian, C. Fendri, M. F. K. Missoum, N. Bouzouaia, K. Rahal, A. Savey, M. Saadatian-Elahi, J. Fabry, Multicenter pilot survey of resistant bacteria in the Mediterranean area European Journal of Clinical Microbiology & Infectious Diseases. ,vol. 25, pp. 340- 343 ,(2006) , 10.1007/S10096-006-0125-Z
P. E. Fournier, H. Richet, R. A. Weinstein, The Epidemiology and Control of Acinetobacter baumannii in Health Care Facilities Clinical Infectious Diseases. ,vol. 42, pp. 692- 699 ,(2006) , 10.1086/500202
Sang-Oh Lee, Nam Joong Kim, Sang-Ho Choi, Tae Hyong Kim, Jin-Won Chung, Jun-Hee Woo, Jiso Ryu, Yang Soo Kim, Risk Factors for Acquisition of Imipenem-Resistant Acinetobacter baumannii: a Case-Control Study Antimicrobial Agents and Chemotherapy. ,vol. 48, pp. 224- 228 ,(2004) , 10.1128/AAC.48.1.224-228.2004
James A. Karlowsky, Deborah C. Draghi, Mark E. Jones, Clyde Thornsberry, Ian R. Friedland, Daniel F. Sahm, Surveillance for Antimicrobial Susceptibility among Clinical Isolates of Pseudomonas aeruginosa and Acinetobacter baumannii from Hospitalized Patients in the United States, 1998 to 2001 Antimicrobial Agents and Chemotherapy. ,vol. 47, pp. 1681- 1688 ,(2003) , 10.1128/AAC.47.5.1681-1688.2003
A FERRARA, Potentially multidrug-resistant non-fermentative Gram-negative pathogens causing nosocomial pneumonia International Journal of Antimicrobial Agents. ,vol. 27, pp. 183- 195 ,(2006) , 10.1016/J.IJANTIMICAG.2005.11.005
Wing Wai Wong, Chang Phone Fung, Cheng Yi Liu, Kwok Woon Yu, Chung Hsu Lai, Hsin Pai Chen, Te Li Chen, Predictors of mortality in Acinetobacter baumannii bacteremia. Journal of Microbiology Immunology and Infection. ,vol. 38, pp. 127- 136 ,(2005)