Epidemiology of Bloodstream Infections Caused by Acinetobacter baumannii and Impact of Drug Resistance to both Carbapenems and Ampicillin-Sulbactam on Clinical Outcomes

摘要: Acinetobacter baumannii has become a leading cause of bloodstream infections (BSI) in health care settings. Although the incidence infection with carbapenem- and ampicillin-sulbactam-resistant (CASR) A. increased, there is scarcity studies which investigate BSI caused by CASR baumannii. A retrospective cohort study was conducted on adult patients who were admitted to Detroit Medical Center between January 2006 April 2009. records queried for patients' demographics, antimicrobial exposures, comorbidities, hospital stay, clinical outcomes. Bivariate analyses logistic regression employed study. Two hundred seventy-four included study: 68 (25%) 206 (75%) non-CASR In multivariate analysis, factors associated admission rapidly fatal condition (odds ratio [OR] = 2.83, 95% confidence interval [CI] 1.27 6.32, P value 0.01) prior use antimicrobials (OR CI 1.18 6.78, 0.02). In-hospital mortality rates significantly higher than those baumannii-induced (43% versus 20%; OR 3.0, 1.60 5.23, < 0.001). However, after adjusting potential confounders, association increased risk in-hospital not significant 1.15, 0.51 2.63, 0.74). This demonstrated that had distinct epidemiology compared more susceptible strains; however, outcomes similar two groups. Admission an independent predictor both mortality.