Association of restless legs syndrome and cardiovascular disease in the Sleep Heart Health Study

摘要: Objective: We evaluated the cross-sectional association between restless legs syndrome (RLS) and prevalent cardiovascular disease (CVD) in a large community-based sample of middle-aged elderly subjects. Methods: This is observational study 1,559 men 1,874 women (mean age 67.9 years) who were enrolled Sleep Heart Health Study, consequences sleep-disordered breathing. RLS was defined by positive responses on self-administered questionnaire to four diagnostic criteria, with symptoms occurring at least five times per month associated moderate distress. Coronary artery (CAD) determined self-report doctor-diagnosed angina, myocardial infarction, or coronary revascularization procedure. Total CVD included CAD history physician-diagnosed stroke heart failure. The relation examined multivariable logistic regression models Results: present 6.8% (n = 128) 3.3% 51). After adjustment for age, sex, race, body mass index, diabetes mellitus, systolic blood pressure, antihypertensive medication use, total:high-density lipoprotein cholesterol ratio, smoking history, ORs 2.05 (95% CI 1.38 3.04) 2.07 (1.43 3.00) subjects compared those without RLS. associations stronger 16 severe than moderately bothersome symptoms. Conclusions: Restless disease. appears greater frequency severity GLOSSARY: AHI apnea-hypopnea index; disease; DBP diastolic pressure; ESRD end-stage renal HDL high-density lipoprotein; IQR interquartile range; LDL low-density OSA obstructive sleep apnea; OSAH apnea/hypopnea; PLMS periodic leg movements sleep; syndrome; SBP SHHS Study.