Norfloxacin versus co-trimoxazole in the treatment of acute bacterial diarrhoea: a placebo controlled study.

摘要: The bacteriological and clinical efficacy of norfloxacin 400 mg b.i.d. was compared to those co-trimoxazole (160 trimethoprim plus 800 sulphamethoxazole) placebo for the treatment acute bacterial diarrhoea in a randomized double-blind trial. Of total 450 patients with diarrhoea, 303 had positive cultures were evaluable efficacy. time elimination pathogens significantly (p less than 0.001) shorter group groups. At completion treatment, cure found 97.9%, 72.4% 38.2% treated norfloxacin, placebo, respectively. All susceptible none them developed resistance during treatment. In group, that antibiotic increased from 2% at inclusion 65.6% end 0.001). shigellosis or cholera, mean normalization bowel movements groups 0.05 p 0.01, respectively). There no significant differences between respect adverse events reported. conclusion, well tolerated highly effective diarrhoea.