Methods of producing high titer, high purity virus stocks and methods of use thereof

摘要: The purity and titer of virus stocks used for clearance studies have a significant influence on study outcome, impact how well the scale-down model represents production-scale process. Impurities in are particularly important testing small retentive filters because these impurities may cause filter to foul prematurely, leading underestimation true throughput capability consequent inappropriate sizing production scale unit. In addition, can also affect levels observed by altering fouling mechanisms subsequent fluid passage through filter. Described herein methods making, producing using high having titer.