Diagnosis of illnesses or predisposition to certain illnesses

作者: Alexander Olek , Christian Piepenbrock , Kurt Berlin

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摘要: The invention relates to a set of oligomer probes (oligonucleotides and/or PNA oligomers) which are used for detecting the cytosine methylation state in nucleic acids. Said especially suitable diagnosing illnesses by analysing group genetic epigenetic parameters.

参考文章(5)
Alexander Olek, Sven Stefan Olek, Joern Walter, Method for producing complex dna methylation fingerprints ,(1998)
J. G. Herman, J. R. Graff, S. Myohanen, B. D. Nelkin, S. B. Baylin, Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands Proceedings of the National Academy of Sciences of the United States of America. ,vol. 93, pp. 9821- 9826 ,(1996) , 10.1073/PNAS.93.18.9821
T. Rein, M. L. DePamphilis, H. Zorbas, Identifying 5-methylcytosine and related modifications in DNA genomes Nucleic Acids Research. ,vol. 26, pp. 2255- 2264 ,(1998) , 10.1093/NAR/26.10.2255
Daniela Volonté, Ferruccio Galbiati, Shengwen Li, Kazutoshi Nishiyama, Takashi Okamoto, Michael P. Lisanti, Flotillins/cavatellins are differentially expressed in cells and tissues and form a hetero-oligomeric complex with caveolins in vivo. Characterization and epitope-mapping of a novel flotillin-1 monoclonal antibody probe. Journal of Biological Chemistry. ,vol. 274, pp. 12702- 12709 ,(1999) , 10.1074/JBC.274.18.12702
Thomas R. Gingeras, Stephen P. A. Fodor, Earl A. Hubbell, Peter E. Lobban, Nila Shah, Macdonald S. Morris, Charles Garrett Miyada, Robert J. Lipshutz, Xiaohua C. Huang, Maureen T. Cronin, Mark Chee, Edward L. Sheldon, Arrays of nucleic acid probes on biological chips ,(1994)