Molecular mechanisms and cell signaling of 20-hydroxyeicosatetraenoic acid in vascular pathophysiology.
作者： Fan Fan , Ying Ge , Wenshan Lv , Matthew R Elliott , Yoshikazu Muroya
DOI: 10.2741/4379
关键词:
摘要: Cytochrome P450s enzymes catalyze the metabolism of arachidonic acid to epoxyeicosatrienoic acids (EETs), dihydroxyeicosatetraenoic and hydroxyeicosatetraeonic (HETEs). 20-HETE is a vasoconstrictor that depolarizes vascular smooth muscle cells by blocking K+ channels. EETs serve as endothelial derived hyperpolarizing factors. Inhibition formation impairs myogenic response autoregulation renal cerebral blood flow. Changes in have been reported hypertension drugs target these pathways alter pressure animal models. Sequence variants CYP4A11 CYP4F2 produce 20-HETE, UDP-glucuronosyl transferase involved biotransformation soluble epoxide hydrolase inactivates are associated with human studies. contributes regulation hypertrophy, restenosis, angiogenesis inflammation. It also promotes dysfunction vasospasm ischemia-reperfusion injury brain, kidney heart. This review will focus on role dysfunction, inflammation, ischemic hemorrhagic stroke cardiac ischemia reperfusion injury.
bioscience.org参考文章(363)
Alex Y Tan, Peter Zimetbaum, 20-Hydroxyeicosatetraenoic acid induces apoptosis in neonatal rat cardiomyocytes through mitochondrial-dependent pathways. Journal of Cardiovascular Pharmacology. ,vol. 57, pp. 294- 301 ,(2011) , 10.1097/FJC.0B013E3182073C78
M. Rosolowsky, W. B. Campbell, Role of PGI2 and epoxyeicosatrienoic acids in relaxation of bovine coronary arteries to arachidonic acid. American Journal of Physiology-heart and Circulatory Physiology. ,vol. 264, ,(1993) , 10.1152/AJPHEART.1993.264.2.H327
Luis H Toledo-Pereyra, F Lopez-Neblina, Alexander H Toledo, Jon Walsh, Molecular signaling pathways in ischemia/reperfusion. Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation. ,vol. 2, pp. 174- 177 ,(2004)
Farid Ljuca, Gorazd Drevenšek, Endothelin-1 induced vascular smooth muscle cell proliferation is mediated by cytochrome p-450 arachidonic acid metabolites. Bosnian Journal of Basic Medical Sciences. ,vol. 10, pp. 223- 226 ,(2010) , 10.17305/BJBMS.2010.2691
D. R. Harder, D. Gebremedhin, J. Narayanan, C. Jefcoat, J. R. Falck, W. B. Campbell, R. Roman, Formation and action of a P-450 4A metabolite of arachidonic acid in cat cerebral microvessels American Journal of Physiology-Heart and Circulatory Physiology. ,vol. 266, pp. H2098- H2107 ,(1994) , 10.1152/AJPHEART.1994.266.5.H2098
Cytochrome P450 4A Expression and Arachidonic Acid Omega-Hydroxylation in the Kidney of the Spontaneously Hypertensive Rat Nephron. ,vol. 73, pp. 652- 663 ,(1996) , 10.1159/000189154
Gwóźdź B, Jośko J, Jedrzejowska-Szypuła H, Hendryk S, Gawlik R, Herman Zs, Influence endothelin ETA receptor antagonist--BQ-123--on changes of endothelin-1 level in plasma of rats with acute vasospasm following subarachnoid hemorrhage. Journal of Physiology and Pharmacology. ,vol. 49, pp. 367- 375 ,(1998)
Amanda L. Johnson, Katheryne Z. Edson, Rheem A. Totah, Allan E. Rettie, Cytochrome P450 ω-Hydroxylases in Inflammation and Cancer Advances in pharmacology (San Diego). ,vol. 74, pp. 223- 262 ,(2015) , 10.1016/BS.APHA.2015.05.002
Kathleen M. Knights, Andrew Rowland, John O. Miners, Renal drug metabolism in humans: the potential for drug–endobiotic interactions involving cytochrome P450 (CYP) and UDP-glucuronosyltransferase (UGT) British Journal of Clinical Pharmacology. ,vol. 76, pp. 587- 602 ,(2013) , 10.1111/BCP.12086
P R Ortiz de Montellano, N O Reich, Specific inactivation of hepatic fatty acid hydroxylases by acetylenic fatty acids. Journal of Biological Chemistry. ,vol. 259, pp. 4136- 4141 ,(1984) , 10.1016/S0021-9258(17)43020-1