Solid Dispersion - a Pragmatic Method to Improve the Bioavailability of Poorly Soluble Drugs

摘要: Drugs contained in solid oral dosage forms need to have good solubility order result bioavailability provided they also permeability. Recently, controlled release systems utilize dispersion technology achieve an extended profile of poorly water-soluble drugs with a short biological half-life. There are two main methods for the preparation dispersions: one is through use liquid phase such as melting and solvent methods, other mechanical methods. Ball milling has been widely used make amorphous phase. Factors which can affect physical stability dispersions investigated widely, glass transition temperatures (Tg), molecular mobility, alone, miscibility between polymers, polymers considered key factors influencing dispersions.