Unacylated ghrelin and obestatin increase islet cell mass and prevent diabetes in streptozotocin-treated newborn rats

摘要: The ghrelin gene products, namely acylated (AG), unacylated (UAG), and obestatin (Ob), were shown to prevent pancreatic beta-cell death improve function under treatment with cytokines, which are major cause of destruction in diabetes. Moreover, AG had been described previously streptozotocin (STZ)-induced diabetes rats; however, the effect either UAG or Ob has never examined this context. In present study, we investigated potential increase islet mass reduce at adult age STZ-treated neonatal rats. One-day-old rats injected STZ subsequently administered AG, for 7 days. On day 70, plasma glucose levels, insulin area number, pancreatic/duodenal homeobox-1 (Pdx1) expression, antiapoptotic BCL2 protein expression determined. Similarly both counteracted STZ-induced high levels improved reduced by diabetogenic compound. increased area, respect alone. Finally, animals, up-regulated Pdx1 mRNA similarly AG. Taken together, our results suggest that newborn rats, metabolism preserve cell mass, granting a therapeutic medical conditions associated impaired function.