The interplay between bioactive sphingolipids and steroid hormones.

摘要: Steroid hormones regulate various physiological processes including development, reproduction, and metabolism. These regulatory molecules are synthesized from cholesterol in endocrine organs -such as the adrenal glands gonads- via a multi-step enzymatic process that is catalyzed by cytochrome P450 superfamily of monooxygenases hydroxysteroid dehydrogenases. Steroidogenesis induced trophic peptide primarily activation cAMP/protein kinase A (PKA)-dependent pathway. However, other signaling molecules, cytokines growth factors, control steroid hormone biosynthetic More recently, sphingolipids, ceramide, sphingosine-1-phosphate, sphingosine, have been found to modulate secretion at multiple levels. In this review, we provide brief overview mechanisms which sphingolipids steroidogenesis. addition, discuss how sphingolipid Finally, outline evidence supporting emerging role bioactive nuclear for metabolism gene transcription.