Pineal gland hormone melatonin binds and activates an orphan of the nuclear receptor superfamily.
作者： M Becker-André , I Wiesenberg , N Schaeren-Wiemers , E André , M Missbach
DOI: 10.1016/S0021-9258(19)61934-4
关键词:
摘要: Nuclear orpan receptors are members of the superfamily structurally related, ligand-inducible transcription factors for which no ligand has yet been identified. Over past few years many nuclear orphan have cloned, but only retinoid X receptor (RXR) a natural (9-cis-retinoic acid) found. Here we report identification melatonin as recently cloned Z beta (RZR beta). We found RZR expression in rat brain nearly coincident with binding sites pineal gland hormone (5-methoxy-N-acetyltryptamine). show here and activation by Kd EC50 values low nanomolar range. A signaling pathway may contribute to some diverse profound effects this hormone, example, context circadian rhythmicity.
sci-hub.st 参考文章(33)
M. Schräder, I. Bendik, M. Becker-André, C. Carlberg, Interaction between retinoic acid and vitamin D signaling pathways. Journal of Biological Chemistry. ,vol. 268, pp. 17830- 17836 ,(1993) , 10.1016/S0021-9258(17)46779-2
R.W. Katz, R.J. Koenig, Nonbiased identification of DNA sequences that bind thyroid hormone receptor alpha 1 with high affinity. Journal of Biological Chemistry. ,vol. 268, pp. 19392- 19397 ,(1993) , 10.1016/S0021-9258(19)36527-5
M. Schräder, M. Becker-André, C. Carlberg, Thyroid hormone receptor functions as monomeric ligand-induced transcription factor on octameric half-sites. Consequences also for dimerization. Journal of Biological Chemistry. ,vol. 269, pp. 6444- 6449 ,(1994) , 10.1016/S0021-9258(17)37392-1
Michael Becker-André, Absolute levels of mRNA by polymerase chain reaction-aided transcript titration assay. Methods in Enzymology. ,vol. 218, pp. 420- 445 ,(1993) , 10.1016/0076-6879(93)18034-A
M. Schräder, K.M. Müller, C. Carlberg, Specificity and flexibility of vitamin D signaling. Modulation of the activation of natural vitamin D response elements by thyroid hormone. Journal of Biological Chemistry. ,vol. 269, pp. 5501- 5504 ,(1994) , 10.1016/S0021-9258(17)37487-2
C Carlberg, R Hooft van Huijsduijnen, J K Staple, J F DeLamarter, M Becker-André, RZRs, a new family of retinoid-related orphan receptors that function as both monomers and homodimers. Molecular Endocrinology. ,vol. 8, pp. 757- 770 ,(1994) , 10.1210/MEND.8.6.7935491
Arthur A. Levin, Laurie J. Sturzenbecker, Sonja Kazmer, Thomas Bosakowski, Christine Huselton, Gary Allenby, Jeffrey Speck, Cl. ratzeisen, Michael Rosenberger, Allen Lovey, Joseph F. Grippo, 9-Cis retinoic acid stereoisomer binds and activates the nuclear receptor RXRα Nature. ,vol. 355, pp. 359- 361 ,(1992) , 10.1038/355359A0
Dario Acuña-Castroviejo, Russel J. Reiter, Armando Menendez-Pelaez, Maria I. Pablos, Alejandro Burgos, Characterization of high‐affinity melatonin binding sites in purified cell nuclei of rat liver Journal of Pineal Research. ,vol. 16, pp. 100- 112 ,(1994) , 10.1111/J.1600-079X.1994.TB00089.X
Peter J. Morgan, Perry Barrett, H.Edward Howell, Rachel Helliwell, Melatonin receptors: Localization, molecular pharmacology and physiological significance Neurochemistry International. ,vol. 24, pp. 101- 146 ,(1994) , 10.1016/0197-0186(94)90100-7
T. Ebisawa, S. Karne, M. R. Lerner, S. M. Reppert, Expression cloning of a high-affinity melatonin receptor from Xenopus dermal melanophores. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 91, pp. 6133- 6137 ,(1994) , 10.1073/PNAS.91.13.6133