Risk of retinal neovascularization in cases of uveitis

摘要: Purpose To evaluate the risk of and factors for retinal neovascularization (NV) in cases uveitis. Design Retrospective cohort study. Participants Patients with uveitis at 4 US academic ocular inflammation subspecialty practices. Methods Data were ascertained by standardized chart review. Prevalence data analysis used logistic regression. Incidence survival time-updated covariates where appropriate. Main Outcome Measures incidence NV. Results Among uveitic eyes 8931 patients presenting initial evaluation, 106 13 810 had NV (prevalence = 0.77%, 95% confidence interval [CI], 0.60–0.90). Eighty-eight more developed over 26 465 eye-years (incidence, 0.33%/eye-year; CI, 0.27–0.41). Factors associated incident include age 35 years (adjusted hazard ratio [aHR], 2.4; 1.5–3.9), current cigarette smoking (aHR, 1.9; 1.1–3.4), systemic lupus erythematosus 3.5, 1.1–11). Recent diagnosis was an increased (compared diagnosed >5 ago, aHR, 2.4 [95% 1.1–5.0] 2.6 1.2–6.0] within Conclusions Retinal is a rare complication uveitis, which occurs frequently younger patients, smokers, those intermediate/posterior/panuveitis, vasculopathy, vascular disease, or active inflammation. Inflammation likely are linked; additional studies needed to further elucidate this connection.