Evolutionary Ecology of Wolbachia Releases for Disease Control.

摘要: Wolbachia is an endosymbiotic Alphaproteobacteria that can suppress insect-borne diseases through decreasing host virus transmission (population replacement) or population density suppression). We contrast natural infections in insect populations with transinfections mosquitoes to gain insights into factors potentially affecting the long-term success of releases. Natural spread rapidly, whereas slow governed by deleterious effects on fitness and demographic factors. Cytoplasmic incompatibility (CI) generated central both replacement suppression programs, but CI nature be variable evolve, as blocking. also influenced environmental decrease titer reduce maternal frequency. More information needed interactions between nuclear/mitochondrial genomes, interaction invasion local ecological factors, stability Wolbachia-mediated