Direct determination of the binding sites of cisplatin on insulin-like growth factor-1 by top-down mass spectrometry.
作者： Ningbo Zhang , Huan Liu , Meng Cui , Yonggang Du , Zhiqiang Liu
DOI: 10.1007/S00775-014-1202-X
关键词:
摘要: Cisplatin has been widely used in the chemotherapy of a variety tumors, and interactions cisplatin with proteins play very important roles its side effects drug resistance, as well pharmacokinetics biodistribution. Insulin-like growth factor-1 (IGF-1) was found to be associated resistance cisplatin. Here, interaction between IGF-1 investigated using electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry. IGF-1-Pt(NH3)Cl main mono-adduct trans labilization reaction cisplatin, while another special IGF-1-Pt(NH3)Cl2 observed. The rapid sensitive top-down spectrometry-based approach linear trap spectrometer developed identify binding sites directly without tedious enzyme digestion. Three (Met59, Arg56 Cys6) were determined. results not only provide efficient way platinum proteins, but also indicate that could promote fragmentation rupture disulfide bond.
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