Iron repletion is associated with reduction in platelet counts in non-dialysis chronic kidney disease patients independent of erythropoiesis-stimulating agent use: a retrospective cohort study

摘要: Iron deficiency is common in non-dialysis chronic kidney disease (ND-CKD) patients and, on occasion, requires parenteral iron therapy. We investigated the effect of intravenous repletion platelet counts ND-CKD with and without concomitant darbepoetin administration. conducted a retrospective analysis anemia treated low molecular weight dextran (LMWID) between 2005 2009 at our CKD clinic. The primary end-point was change count 60 days post infusion LMWID those Secondary end-points were correlations changes indices. A total 108 met inclusion exclusion criteria. decrease response to statistically significant (305.72 ± 108.86 vs 255.58 ± 78.97, P = < .0001). independent use. Bivariate regression baseline transferrin saturation by (TSAT) showed negative association (βTSAT = −5.82, P = .0007) moderate correlation (R = 0.32). Following treatment, within individual not related TSAT (βΔTSAT = −0.41, P = .399) demonstrated poor (R = 0.10). Parenteral treatment associated reduction deficient anemic patients. However, ESA use majority prior administration could have altered production through bone marrow competition.