Potential role of Shh-Gli1-BMI1 signaling pathway nexus in glioma chemoresistance.
作者： M. H. Shahi , S. Farheen , M. P. M. Mariyath , J. S. Castresana
DOI: 10.1007/S13277-016-5365-7
关键词:
摘要: Chemoresistance is a common hurdle for the proper treatment of gliomas. The role Shh-Gli1 signaling in glioma progression has been reported. However, its chemoresistance not well studied yet. In this work, we found that regulates expression one stem cell marker, BMI1 (B cell-specific Moloney murine leukemia virus), glioma. Interestingly, also demonstrated high MRP1 (multi-drug resistance protein 1) was decreased by siRNA and specific inhibitor GANT61 our experiments. very efficiently inhibited colony growth lines, compared to temozolomide. Moreover, synergic effect temozolomide drastically LD50 Therefore, results suggest there potential nexus Shh-Gli1-BMI1 regulate promote Henceforth, study opens possibility facing new targets, Gli1 BMI1, effective suppression with adjuvant therapy
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