Thymalfasin for the treatment of chronic hepatitis B
作者： Rong-Nan Chien , Yun-Fan Liaw
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摘要: Chronic hepatitis B virus infection is a serious problem because of its worldwide distribution and possible adverse chronic sequelae, such as cirrhosis hepatocellular carcinoma. dynamic state interactions between the virus, hepatocyte host immune response. Interferon-Α direct antiviral agents, lamivudine (Epivir®, GlaxoSmithKline), are effective in therapy HBV but efficacy far from satisfactory. Thymalfasin (thymosin Α1; TΑ1, Zadaxin™, SciClone Pharmaceuticals, Inc.) 28-amino acid polypeptide produced synthetically originally isolated thymosin fraction 5, bovine thymus extract containing number immunologically active peptides. In vitro studies have shown that TΑ1 can influence T-cell production maturation, stimulate Th1 cytokines interferon-Γ interleukin-2, activate natural killer cell-mediated cytotoxicity. Seven randomized controlled on monotherapy ...
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