Onion and garlic extracts lessen cadmium-induced nephrotoxicity in rats
作者： Stephen M. Suru
DOI: 10.1007/S10534-008-9148-5
关键词:
摘要: Cadmium (Cd) is a well-known nephrotoxicant inducing kidney damage via oxidative stress. Since the critical target organ of Cd toxicity, this study was designed to evaluate protective effects onion (Allium cepa L.) and garlic sativum aqueous extracts on Cd-induced renal stress in male Wistar rats. The control group received double distilled water alone challenged with 3CdSO4 · 8H2O (as Cd) (1.5 mg/100 g bw/day per oral) alone. Extract-treated groups were pre-treated varied doses (0.5 ml 1.0 ml/100 g bw/day and/or extract for 1 week after which they co-treated (1.5 mg/100 g bw/day 3 weeks. results showed that levels lipid peroxidation (LPO) glutathione-S transferase (GST) significantly (P < 0.001) increased rats relative group. More so, glutathione (GSH), superoxide dismutase (SOD), catalase (CAT) Na+/K+-ATPase decreased Treatment Cd-intoxicated (P < 0.05) restored alterations these parameters While treatment high dose exerted significant dose-dependent restoration parameters, elicited pro-oxidant effect, their respective low dose. Our suggests may exert reduction LPO enhanced antioxidant defense. These may, therefore, be useful nutritional option alleviating damage.
springer.com
sci-hub.se 参考文章(56)
L. Pari, P. Murugavel, S.L. Sitasawad, K. Sandeep Kumar, Cytoprotective and antioxidant role of diallyl tetrasulfide on cadmium induced renal injury: an in vivo and in vitro study. Life Sciences. ,vol. 80, pp. 650- 658 ,(2007) , 10.1016/J.LFS.2006.10.013
S.K Banerjee, M Maulik, S.C Manchanda, A.K Dinda, T.K Das, S.K Maulik, Garlic-induced alteration in rat liver and kidney morphology and associated changes in endogenous antioxidant status. Food and Chemical Toxicology. ,vol. 39, pp. 793- 797 ,(2001) , 10.1016/S0278-6915(01)00018-7
K. T. Augusti, C. G. Sheela, Antiperoxide effect of S-allyl cysteine sulfoxide, an insulin secretagogue, in diabetic rats. Cellular and Molecular Life Sciences. ,vol. 52, pp. 115- 120 ,(1996) , 10.1007/BF01923354
Agneta Åkesson, Thomas Lundh, Marie Vahter, Per Bjellerup, Jonas Lidfeldt, Christina Nerbrand, Göran Samsioe, Ulf Strömberg, Staffan Skerfving, Tubular and glomerular kidney effects in Swedish women with low environmental cadmium exposure. Environmental Health Perspectives. ,vol. 113, pp. 1627- 1631 ,(2005) , 10.1289/EHP.8033
D.J. Stewart, Sensitive automated methods for phosphate and (Na+ + K+)-ATPase Analytical Biochemistry. ,vol. 62, pp. 349- 364 ,(1974) , 10.1016/0003-2697(74)90167-5
Soisungwan Satarug, Michael R. Moore, Adverse health effects of chronic exposure to low-level cadmium in foodstuffs and cigarette smoke Environmental Health Perspectives. ,vol. 112, pp. 1099- 1103 ,(2004) , 10.1289/EHP.6751
Ana I. Morales, César Vicente-Sánchez, Mirjana Jerkic, José M. Santiago, Penélope D. Sánchez-González, Fernando Pérez-Barriocanal, José M. López-Novoa, Effect of quercetin on metallothionein, nitric oxide synthases and cyclooxygenase-2 expression on experimental chronic cadmium nephrotoxicity in rats Toxicology and Applied Pharmacology. ,vol. 210, pp. 128- 135 ,(2006) , 10.1016/J.TAAP.2005.09.006
Fatma M El-Demerdash, Mokhtar I Yousef, Fatma S Kedwany, Hoda H Baghdadi, None, Cadmium-induced changes in lipid peroxidation, blood hematology, biochemical parameters and semen quality of male rats: protective role of vitamin E and β-carotene Food and Chemical Toxicology. ,vol. 42, pp. 1563- 1571 ,(2004) , 10.1016/J.FCT.2004.05.001
A. M. Massadeh, S. A. Al-Safi, I. F. Momani, A. A. Alomary, Q. M. Jaradat, A. S. AlKofahi, Garlic (Allium sativum L.) as a potential antidote for cadmium and lead intoxication: cadmium and lead distribution and analysis in different mice organs. Biological Trace Element Research. ,vol. 120, pp. 227- 234 ,(2007) , 10.1007/S12011-007-8017-3
F.M. El-Demerdash, M.I. Yousef, N.I. Abou El-Naga, Biochemical study on the hypoglycemic effects of onion and garlic in alloxan-induced diabetic rats Food and Chemical Toxicology. ,vol. 43, pp. 57- 63 ,(2005) , 10.1016/J.FCT.2004.08.012