Vanadate is a potent (Na,K)-ATPase inhibitor found in ATP derived from muscle.
作者： L.C. Cantley , L. Josephson , R. Warner , M. Yanagisawa , C. Lechene
DOI: 10.1016/S0021-9258(17)40978-1
关键词:
摘要: A potent (Na,K)-ATPase inhibitor purified from "Sigma Grade* ATP has been identified as vanadium using electron probe microanalysis and confirmed by microwave-induced emission spectroscopy paramagnetic resonance spectroscopy. Sodium orthovanadate (Na3 VO4) is identical with the respect to ultraviolet absorbance, migration on thin layer chromatography, inhibition of (Na,K)-ATPase. The in-inhibited 50% 40 nM Na3 VO4 under optimal conditions (28 mM Mg2+) 100% reversible millimolar concentrations norepinephrine. physiological significance this discussed in relation vivo.
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