Methods and systems for screening using microcapillary arrays

摘要: High-throughput methods for screening large populations of variant proteins are provided. The utilize large-scale arrays microcapillaries, where each microcapillary comprises a solution containing protein, an immobilized target molecule, and reporter element. Immobilized molecules may include any molecule interest, including proteins, nucleic acids, carbohydrates, other biomolecules. association protein with molecular is assessed by measuring signal from the contents microcapillaries identified in assays as interest can be isolated, cells expressing characterized. Also provided systems performing disclosed methods.