Natural Killing of Xenogeneic Cells Mediated by the Mouse Ly-49D Receptor
作者： Christian Naper , Steven C. Spusta , Geoffrey W. Butcher , Bent Rolstad , Eréne C. Niemi
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摘要: NK lymphocytes lyse certain xenogeneic cells without prior sensitization. The receptors by which recognize targets are largely uncharacterized but have been postulated to possess broad specificity against ubiquitous target ligands. However, previous studies suggest that mouse in a strain-specific manner, implicating finely tuned, complex receptor systems xenorecognition. We speculated Ly-49D, an activating for the MHC I ligand, H2-Dd, might display public specificities structures. To test this hypothesis, we examined lysis of Ly-49D transfectants rat cell line RNK-16 (RNK. Ly-49D). Of tumor tested, RNK.Ly-49D, not untransfected RNK-16, preferentially lysed derived from Chinese hamsters and lymphoblast rats. Ly-49D-dependent recognition hamster was independent N-linked glycosylation. Mouse also specifically stimulated natural killing wild-type MHC-congenic rats RT1lv1 RT1l haplotypes, RT1c, RT1u, RT1av1, or RT1n haplotypes. These demonstrate can mediate cytotoxicity cells, they may MHC-encoded
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