Intraarterial chemotherapy for brain tumors by using a spatial dose fractionation algorithm and pulsatile delivery.
作者： Y. Pierre Gobin , Timothy F. Cloughesy , Kira L. Chow , Gary R. Duckwiler , James W. Sayre
DOI: 10.1148/RADIOLOGY.218.3.R01MR41724
关键词:
摘要: PURPOSE: To evaluate the cause of complications in intraarterial chemotherapy for brain tumors and validate a dosage algorithm based on arterial territory. MATERIALS AND METHODS: Four hundred sixty-two procedures were performed 113 patients. Technique included pulsatile infusion chemotherapeutic agent. Dosage was calculated per hemisphere divided territory according to spatial dose fractionation vascular territories major cerebral arteries: middle artery, 60%; anterior 20%; posterior 15%; perforator arteries, 5%. Hospital charts all patients retrospectively reviewed complications, with specific attention given angiograms determine cause. Then, subgroup analysis protocol largest patient population predictors complications. RESULTS: Six (1.3%) asymptomatic; 12 (2.6%), transient neurologic; three (0.6%), perman...
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