Helicobacter pylori Infection, Intestinal Metaplasia, and Gastric Cancer Risk in Eastern Siberia

摘要: Background:  The incidence of gastric cancer (GC) is extremely high in Russia and eastern Siberia, where information on the epidemiology Helicobacter pylori infection fragmentary. Aims:  To assess prevalence both H. pylori (including CagA status) intestinal metaplasia (IM) Russian Siberian populations carrying a different risk GC. Materials Methods:  A sample 2129 consecutive patients was considered, including 689 Europoids 1440 Mongoloids (493 Evenks, 533 Khakass people, 414 Tuvans), who all underwent serum sampling upper gastrointestinal endoscopy. status established (ELISA, urease test, histology), IgG anti-CagA antibodies were assessed (ELISA) H. pylori-positive cases. At least 3 biopsy samples per patient IM scored as present versus absent. H. pylori, CagA+ve status, compared with GC according to regional registries. Results:  similar for (93.6 vs 94.3%). follows: 61.2%, Evenks 36.4%, 44.0%, Tuvans 60.0% (p1vs2 < .001; p1vs3 < .001; p2vs4 < .001; p3vs4 < .001). 10.7%, 5.1%, 9.8%, 23.4% (p1vs2 = .001; p1vs4 < .001; (per 100,000 population/year) 33.2; 18.2; 20.2; 50.7 (p1vs2 = 0.04; p1vs3 = .05; p3vs4 < .001). Conclusion: H. pylori consistently populations; ethnicities had GC. As expected, correlated Host-related and/or environmental factors may explain discrepancies between IM,